Cell: touch the cancer cells to self-destruct - Cell: touch the cancer cells t - 北京普飞特生物科技有限公司
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Cell: touch the cancer cells to self-destruct

Biological pass report Researchers from the university of Washington, construct a kind of protein molecules called "BINDI", and confirmed that

it touches the EB virus infection of cancer cells to self-destruct (read: medical Science: drive small molecules of cancer cells to commit

suicide). This important research results published in the June 19 in the journal "Cell" (Cell). Many cancers are associated with epstein-barr

virus, it can disrupt the body remove aging, abnormal cells, infection and injury. In the resulting mononucleosis and other seizure disorders,

EB virus can persist for a long time. They collapse killed by preventing cell itself and survived. Viruses cause interference to cell group

regulation likely contributed to the excessive cancerous growth. In this article on the Cell, the researchers described their computer design,

build and test of a protein can destroy the EB virus interference effect of the process. They found the BINDI can promote cancer cells atrophy,

decomposition components, EB virus infection and rupture into small pieces. The BINDI protein is constructed from the protein design research

institute at the university of Washington. The lead author of the paper is in the department of biochemistry at the university of Washington

Erik Procko and biological engineering, department of Geoffrey y. Berguig. With, the Fred Hutchinson cancer research center at the university

of Washington, Seattle cancer nursing alliance and Scripps research institute scientists and clinicians for cooperation. The team also in EB

virus positive lymphoma laboratory model test of the protein. Lymphoma is a involving the lymph nodes, spleen, bone marrow, blood and other

body parts, the type of cancer. Researchers will lymphoma tissue transplanted into mice, in order to evaluate the efficacy of the BINDI as a

living system. Scientists with the aid of a new designed to cancer target protein cargo transfer to cell antibody guide nanometer carrier, to

transfer the protein in the cancer cells. BINDI orders: it inhibits tumor growth, make extend the survival time of mice. Researchers said: "we

selectively kill target cells to design some proteins are of particular interest, as compared with the current of other cells to produce toxic

effect of compound, they may be able to offer some advantage." This work also confirmed to develop new possibilities of intracellular protein

drugs, current protein therapy is limited to the extracellular targets. BINDI is designed to identify and adhesion of EB virus BHRF1 protein,

it will ignore other similar protein. BHRF1 makes cancer cells to survive, when combined with BINDI it is no longer able to prevent cell death.

By detecting the BINDI crystal structure, the scientists see it with the computer design of protein molecular structure was almost completely

match. "Protein the tight fit between the model and actual structure highlights our success on development and design of toxins," the

researchers said.